WIMMS
WIMMS
About WIMMS
WIMMS (what is my melanocytic signature) is an interactive Shiny application
for classifying melanocytic cell states.
Previously published gene expression signatures have been collected and clustered into seven principal signatures representing major cell states. Users can compare their signatures to
these signatures to identify their signatures.
User Guide
Download a detailed step-by-step tutorial with screenshots.
1. Click on the 'Identify Your Signature' tab.
2. Put in the name for you signature. Default is 'User's Signature, if left blank.
3. Paste your signature into the text box. Each gene should be on a separate line. If any genes in the signature is not recognized, these genes will show up below the input.
4. Click 'Start Analysis'.
5. Navigate to 'Identity' and 'Overlap Analysis' for results.
6. Click Clear to start a new session.
Result Interpretation
The 'Identity' tab provides information on how your signature relates to other published signatures. Both the dendrogram and the heatmap are the results from hierarchical clustering.
The 'Composition' tab provides information on how your signature relates to all seven signature classes.
The 'Overlap Analysis' tab presents the percentage of number of genes in your signature overlapped with other published signatures.
The 'Biological Insights' tab provides the results from Enrichr of the seven signature classes. This tab ONLY includes information about the seven classes, NOT your signature.
Contact
If you have any questions, please contact:
Min Hu at min.hu@hci.utah.edu
Aik Choon Tan at aikchoon.tan@hci.utah.edu
Robert Judson-Torres at robert.judson-torres@hci.utah.edu
Citation
If you find WIMMS useful, please cite it:
Hu, M., Coleman, S., Judson-Torres, R. L., & Tan, A. C. (2024). The classification of melanocytic gene signatures. Pigment Cell & Melanoma Research, 0, 1-10. https://doi.org/10.1111/pcmr.13189
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